We have an exciting opportunity available for a bright and innovative immunologist to join GSK’s Immunology Research Unit in Stevenage. You will be working in a stimulating and fast-moving environment, where we put great emphasis on high quality science. You will join a group of diverse and experienced biologists focused on identifying new medicines that correct dysfunction at barrier interfaces. Immune cells like macrophages interact with epithelial cells/keratinocytes at the barrier interface and play a key role in pathogen defence and tissue homeostasis. Dysregulated macrophage function at barrier interfaces results in susceptibility to infections and inflammation which are key recurring features of chronic intestinal, airway and skin diseases.
Our role is to identify novel genetically associated targets for barrier diseases in partnership with colleagues in Human Genetics and Functional Genomics, to validate the targets using disease- and mechanism-relevant in vitro cell and tissue-based assays, and to deliver the translational biology packages that support progression of molecules from lead discovery through to early clinical development.
As a Contingency Worker with a background in immunology and/or cell biology, you will have the opportunity to support drug discovery programs with a focus on running established protocols as well as developing new immunological assays to interrogate target biology in a range of cell types, including epithelial cells and immune cells. The selected candidate will be expected to have excellent communication and organizational skills, present results at team and project meetings, and maintain accurate experimental records.
Key Responsibilities include, but are not limited to:
• Contributing to the validation, characterisation and progression of novel targets and therapeutics to treat intestinal and skin diseases.
• Support ongoing target validation assays and establish novel assays to evaluate target biology in immune and/or epithelial cells
• Maintain an active knowledge of external developments in the field and adapting/initiating work plans (internally and externally) in response to emergent data.
• Engagement and sharing expertise with wider Immunology Research Unit.
We are looking for professionals with these required skills to achieve our goals:
• Science graduate with additional research experience - or new PhD in Immunology/ Cell Biology or a related discipline
• Experienced with isolation of primary human immune cells or primary epithelial cell cultures.
• Experienced in several immunological assays to support target validation (e.g. flow cytometry, RNA expression analysis, biochemical analysis of signaling intermediates, measurement of inflammatory mediators using MSD/ELISA, imaging).
• Comprehensive expertise in experimental design, execution and analysis.
• Excellent written and verbal communication skills.
• Ability to work independently and deliver high-quality, consistent results in a timely fashion.
• Ability to prioritize multiple projects effectively and meet timelines successfully with the utmost attention to detail while setting high performance standards.
• Flexible, focused, enthusiastic, and highly motivated.
• Experience with multi-colour flow cytometry
• Experience with primary keratinocyte or skin cultures
• Experience with genetic modification of proteins in primary cells or cell lines (e.g. CRISPR-Cas9, siRNA silencing)
If you feel you would be suitable, please send in your CV