Position: Senior Scientist
Pay Rate: £29.38 Per Hour / Umbrella Company / Inside IR35 / PAYE Option is available
LOA: 1 Year
GlaxoSmithKline (GSK) is committed to developing medicines for global health challenges including respiratory, immuno-inflammation, oncology and infectious diseases. We know that finding cures means not just finding new drugs but finding new ways to discover drugs.
The Immunology Research Unit identifies and develops novel therapeutic targets for patients with unmet medical need, through leveraging strong genetic datasets, building drug hypotheses from output of functional genomic CRISPR editing screens and performing hands-on experimentation using a wide range of molecular and cellular techniques suitable for drug target identification and validation. Our Genomic Immunology group strives to explore that rich data landscape to derive crucial insight, and to integrate directly with our ground-breaking experimental science. This approach maximizes the probability of delivering successful clinical candidates, and ultimately helping people to do more, feel better and live longer.
The Senior Scientist position will reside in the Genomic Immunology Group within the Immunology Research Unit and will be based in Stevenage, UK. The role will allow a highly motivated and skilled candidate to participate in target identification and validation efforts and to take part in the development of novel therapeutics for the treatment of immune disorders with high unmet medical need. This individual will work independently and/or in partnership with cross-functional project teams in a multidisciplinary matrixed environment to evaluate novel immune targets, investigate their biology by using functional molecular genomic tools, and to make significant and high-impact contributions in multiple GSK drug discovery programs.
• Identify and validate discovery targets using human genetics, single cell transcriptomics, cellular assays and/or inflammatory disease models.
• Design and perform molecular and cellular assays suitable for drug target identification and validation.
• Generate, analyse, interpret, present experimental results at various meetings to partners/collaborators and collaboratively plan experimental paths forward.
• Support project teams in collaboration with scientists from multiple functional areas.
• Generate study reports and maintain a detailed record of experiments in electronic lab notebooks in accordance with company policy.
• Share in responsibilities to support general lab functions.
• PhD in Immunology, or related fields or BSc/MSc with relevant work experience.
• Comprehensive understanding of immunology.
• Technical expertise in immune cell isolation and culture, functional assays, multi-parameter flow cytometry and immunoassays.
• Experience in experimental design, execution, assay development and analysis.
• PhD with strong knowledge and research experience in the field of immunology and auto-immune diseases.
• Technical expertise in gene editing.
• Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by a strong publication record and/or significant contributions to therapeutic development programs.
• Strong verbal, written communication skills as well as interpersonal skills.
• Knowledgeable, highly motivated, creative, and collaborative.
• Learning agility and drive to continuously improve and develop.
• Previous drug discovery experience in a bio pharmaceutical setting.