12 Month Contract
Pay: £35.94/h - £47/h
The Immunology Research Unit (IRU) comprises multiple teams of outstanding immunologists and drug discovery experts focused on the identification and validation of a next generation of immunology targets to treat inflammatory diseases.
Within the IRU we are seeking a highly motivated scientist with in vitro and in vivo experience in the field of immunology to join the Experimental Quantitative Pharmacology (eQP ) group based at Stevenage (UK) for 12 months. The successful candidate will work with a high-functioning team of scientists to support the progression of ongoing drug discovery programmes within the IRU portfolio.
In this role, you will be responsible for contributing to the implementation of translational animal model strategies aligned to immunological targets and mechanisms that present new therapeutic opportunities for multiple disease indications. This is an exciting lab-based role that will allow the successful candidate to make a critical contribution to our efforts to develop therapeutics in the area of immunology. Understanding of mechanisms involved in the immune response and having technical in vitro and in vivo expertise in the field of animal models and immunology, the successful candidate will work with eQP scientists and in project matrix teams, to support translational strategies for in vivo target validation and progression of candidate molecules through preclinical research.
You will need to be a creative, innovative self-starter, with excellent verbal and written communication skills, with a desire to contribute from the lab. You will be accountable for generating high quality, robust data and must have the ability to work effectively both independently and as part of a multi-disciplinary matrix team.
Your responsibilities will include:
- Design and utilisation of multi-parameter flow cytometry panels for investigation of immune cell populations, from animal model samples or cell-based ex vivo assays
- Investigation of the mechanism of action of candidate molecules using ELISA assays for protein quantitation and gene expression techniques (qPCR)
- Data analysis, integration and interpretation for timely communication of results to eQP leaders and project teams ability to interpret and report translatable animal model efficacy data
- Accurate data capture in the electronic Lab Note Book system and report writing in line with data integrity standards
- Opportunity to be trained in the design and oversight of animal studies depending on prior experience
- BSc/PhD in immunology, or translational science or pharmacology
- Understanding of mechanisms involved in the immune response in animal model through:
- Hands-on experience in multi-parameter flow cytometry techniques for immunophenotyping and characterisation of cellular responses
- Prior expertise in performing an ELISA assays for protein quantitation and gene analysis by qPCR
- Demonstrated practical laboratory skills gained from working in industrial or academic research environment
- Design and execution of established and new in vitro/ex vivo protocols
- Ability to work independently and to deliver high-quality results in a consistent and timely manner
- Excellent record keeping and organisational skills
- Ability to understand, interpret, and communicate complex scientific data
- Excellent verbal and written communication skills
- Flexible, focused, enthusiastic, and highly motivated
- Ensuring compliance with Values and Policies
- Expertise in the design and oversight of animal studies
- Expertise in cell culture techniques (isolation and culture of primary mouse cells) and in optimisation and execution of cell-based assays (phenotypic and mechanistic)
- Previous research experience working with or in the pharmaceutical industry to support drug discovery programmes.