Scientist (Immunology Research Unit)
Are you energised by a challenging role in biology, where scientific demand is driving team growth? If so, this Scientist role would be a great opportunity to consider.
We are seeking a highly motivated scientist with experience in immunology and gene editing to join the B cell Biology team within the Immunology Research Unit (IRU; Stevenage, UK) for 12 months. The successful candidate will work with a high-functioning team of scientists to identify and validate new targets and to support the progression of ongoing drug discovery programmes within the IRU portfolio.
In this role you will be responsible for validating potential new drug targets and developing novel, robust, in vitro human cell-based immunology assays that recapitulate disease-relevant biology. This is an exciting lab-based role that will allow the successful candidate to make a critical contribution to our efforts to develop therapeutics in the area of immunology at GSK.
You will need to be a creative, innovative self-starter, with excellent verbal and written communication skills, with a desire to contribute from the lab. You will be accountable for generating high quality, robust data and must have the ability to work effectively both independently and as part of a multi-disciplinary matrix team. Additionally, you will need to be proactive and open to the ideas of others while having a deep curiosity and enthusiasm for learning novel approaches and techniques.
Your responsibilities will include:
· Optimisation and application of CRISPR in primary human immune cells for the evaluation and validation of novel targets and cellular function. This will include the use of multiple-parameter flow cytometry and other cell-based assay techniques.
· Investigation of the mechanism of action of small molecule inhibitors using gene expression techniques and phenotypic assays.
· Contributing to project teams by generating strong data packages to support our programmes.
· You will also be given the opportunity to represent the IRU and Company by attending relevant meetings.
We are looking for professionals with these required skills to achieve our goals:
· BSc/MSc/PhD in immunology, molecular biology or related field.
· Relevant experience in cellular immunology.
· Expertise in gene editing and molecular biology techniques (CRISPR, Sanger sequencing, RNA isolation, RT-PCR analysis).
· Significant expertise in cell culture techniques (isolation and culture of primary human cells) and in optimisation and execution of cell-based assays (phenotypic and mechanistic) to support validation of targets and pharmacological evaluation of compounds.
· Hands-on experience in multi-parameter flow cytomety techniques for the characterisation of cellular responses.
· Demonstrated practical laboratory skills gained from working in industrial or academic research environments.
· Excellent record keeping and organisational skills.
· Excellent verbal and written communication skills.
· Ability to work independently and to deliver high-quality results in a consistent and timely manner.
· Ability to prioritise multiple projects effectively and meet timelines successfully with attention to detail while setting high performance standards.
· Ability to understand, interpret, and communicate complex scientific data.
· Design and execution of new and established protocols.
· Flexible, focused, enthusiastic, and highly motivated.
· Fluent spoken / written English.
If you have the following characteristics, it would be a plus:
· Experience in DNA extraction, PCR/primer design and generating samples for sequencing.
· Previous research experience working with or in the pharma industry to support drug discovery programmes.
· Hands-on experimental experience in cell sorting.